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A Protocol for Direct Stereospecific Amination of Primary, Secondary, and Tertiary Alkylboronic Esters.

ABSTRACT: The direct, stereospecific amination of alkylboronic and borinic esters can be conducted by treatment of the organoboron compound with methoxyamine and potassium tert-butoxide. In addition to being stereospecific, this process also enables the direct amination of tertiary boronic esters in an efficient fashion.

SUBMITTER: Edelstein EK

PROVIDER: S-EPMC6322687 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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A Protocol for Direct Stereospecific Amination of Primary, Secondary, and Tertiary Alkylboronic Esters.

Edelstein Emma K EK Grote Andrea C AC Palkowitz Maximilian D MD Morken James P JP

Synlett : accounts and rapid communications in synthetic organic chemistry 20180620 13

The direct, stereospecific amination of alkylboronic and borinic esters can be conducted by treatment of the organoboron compound with methoxyamine and potassium <i>tert</i>-butoxide. In addition to being stereospecific, this process also enables the direct amination of tertiary boronic esters in an efficient fashion. ...[more]

PMID: 30631220

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