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Non-Deprotonative Primary and Secondary Amination of (Hetero)Arylmetals.

ABSTRACT: Herein we disclose a novel method for the facile transfer of primary (-NH2) and secondary amino groups (-NHR) to heteroaryl- as well as arylcuprates at low temperature without the need for precious metal catalysts, ligands, excess reagents, protecting and/or directing groups. This one-pot transformation allows unprecedented functional group tolerance and it is well-suited for the amination of electron-rich, electron-deficient as well as structurally complex (hetero)arylmetals. In some of the cases, only catalytic amounts of a copper(I) salt is required.

SUBMITTER: Zhou Z

PROVIDER: S-EPMC5348115 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Non-Deprotonative Primary and Secondary Amination of (Hetero)Arylmetals.

Zhou Zhe Z Ma Zhiwei Z Behnke Nicole Erin NE Gao Hongyin H Kürti László L

Journal of the American Chemical Society 20161223 1

Herein we disclose a novel method for the facile transfer of primary (-NH<sub>2</sub>) and secondary amino groups (-NHR) to heteroaryl- as well as arylcuprates at low temperature without the need for precious metal catalysts, ligands, excess reagents, protecting and/or directing groups. This one-pot transformation allows unprecedented functional group tolerance and it is well-suited for the amination of electron-rich, electron-deficient as well as structurally complex (hetero)arylmetals. In some ...[more]

PMID: 28004917

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