Ontology highlight
ABSTRACT:
SUBMITTER: Grinde KE
PROVIDER: S-EPMC6330129 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Grinde Kelsey E KE Qi Qibin Q Thornton Timothy A TA Liu Simin S Shadyab Aladdin H AH Chan Kei Hang K KHK Reiner Alexander P AP Sofer Tamar T
Genetic epidemiology 20181015 1
Polygenic risk scores (PRSs) are weighted sums of risk allele counts of single-nucleotide polymorphisms (SNPs) associated with a disease or trait. PRSs are typically constructed based on published results from Genome-Wide Association Studies (GWASs), and the majority of which has been performed in large populations of European ancestry (EA) individuals. Although many genotype-trait associations have generalized across populations, the optimal choice of SNPs and weights for PRSs may differ betwee ...[more]