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Quantitative 1H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets.

ABSTRACT: A simple, rapid, accurate, and selective quantitative nuclear magnetic resonance method for the determination of tadalafil in bulk drugs and its tablets was established and evaluated. Spectra were obtained in dimethylsulfoxide-d6 using 2,4-dinitrotoluene as the internal standard. In this study, the method's linearity, range, limit of quantification, stability, precision, and accuracy were validated. The results were consistent with those obtained from high-performance liquid chromatography analysis. Thus, the proposed method is a useful and practical tool for the determination of tadalafil in bulk drugs and its tablets.

SUBMITTER: Yang Q

PROVIDER: S-EPMC6332277 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Quantitative 1H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets.

Yang Qingyun Q Qiu Hui H Guo Wei W Wang Dongmei D Zhou Xingning X Xue Dan D Zhang Jinlan J Wu Song S Wang Yinghong Y

Molecules (Basel, Switzerland) 20150702 7

A simple, rapid, accurate, and selective quantitative nuclear magnetic resonance method for the determination of tadalafil in bulk drugs and its tablets was established and evaluated. Spectra were obtained in dimethylsulfoxide-d6 using 2,4-dinitrotoluene as the internal standard. In this study, the method's linearity, range, limit of quantification, stability, precision, and accuracy were validated. The results were consistent with those obtained from high-performance liquid chromatography analy ...[more]

PMID: 26147583

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