Ontology highlight
ABSTRACT:
SUBMITTER: Hur WS
PROVIDER: S-EPMC6333891 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Hur Woosuk S WS Mazinani Nima N Lu X J David XJD Yefet Leeor S LS Byrnes James R JR Ho Laura L Yeon Ju Hun JH Filipenko Sam S Wolberg Alisa S AS Jefferies Wilfred A WA Kastrup Christian J CJ
The Journal of biological chemistry 20181108 2
In cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD), the amyloid β (Aβ) peptide deposits along the vascular lumen, leading to degeneration and dysfunction of surrounding tissues. Activated coagulation factor XIIIa (FXIIIa) covalently cross-links proteins in blood and vasculature, such as in blood clots and on the extracellular matrix. Although FXIIIa co-localizes with Aβ in CAA, the ability of FXIIIa to cross-link Aβ has not been demonstrated. Using Western blotting, kinetic assays ...[more]