Ontology highlight
ABSTRACT:
SUBMITTER: Klein HL
PROVIDER: S-EPMC6334232 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Microbial cell (Graz, Austria) 20190107 1
Genomes are constantly in flux, undergoing changes due to recombination, repair and mutagenesis. <i>In vivo</i>, many of such changes are studies using reporters for specific types of changes, or through cytological studies that detect changes at the single-cell level. Single molecule assays, which are reviewed here, can detect transient intermediates and dynamics of events. Biochemical assays allow detailed investigation of the DNA and protein activities of each step in a repair, recombination ...[more]