Ontology highlight
ABSTRACT:
SUBMITTER: Acosta-Alvear D
PROVIDER: S-EPMC6336407 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Acosta-Alvear Diego D Karagöz G Elif GE Fröhlich Florian F Li Han H Walther Tobias C TC Walter Peter P
eLife 20181224
The protein folding capacity of the endoplasmic reticulum (ER) is tightly regulated by a network of signaling pathways, known as the unfolded protein response (UPR). UPR sensors monitor the ER folding status to adjust ER folding capacity according to need. To understand how the UPR sensor IRE1 maintains ER homeostasis, we identified zero-length crosslinks of RNA to IRE1 with single nucleotide precision <i>in vivo</i>. We found that IRE1 specifically crosslinks to a subset of ER-targeted mRNAs, S ...[more]