Ontology highlight
ABSTRACT:
SUBMITTER: Song H
PROVIDER: S-EPMC6946866 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Song Heyu H Zeng Jiping J Roychoudhury Shrabasti S Biswas Pranjal P Mohapatra Bhopal B Ray Sutapa S Dowlatshahi Kayvon K Wang Jing J Band Vimla V Talmon Geoffrey G Bhakat Kishor K KK
Molecular cancer therapeutics 20191001 1
Fluorouracil (5-FU) remains a first-line chemotherapeutic agent for colorectal cancer. However, a subset of colorectal cancer patients who have defective mismatch-repair (dMMR) pathway show resistance to 5-FU. Here, we demonstrate that the efficacy of 5-FU in dMMR colorectal cancer cells is largely dependent on the DNA base excision repair (BER) pathway. Downregulation of APE1, a key enzyme in the BER pathway, decreases IC<sub>50</sub> of 5-FU in dMMR colorectal cancer cells by 10-fold. Furtherm ...[more]