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Targeting Multiple Receptors to Increase Checkpoint Blockade Efficacy.

ABSTRACT: Immune checkpoint blockade therapy is a powerful treatment strategy for many cancer types. Many patients will have limited responses to monotherapy targeted to a single immune checkpoint. Both inhibitory and stimulatory immune checkpoints continue to be discovered. Additionally, many receptors previously identified to play a role in tumor formation and progression are being found to have immunomodulatory components. The success of immunotherapy depends on maximizing pro-anti-tumor immunity while minimizing immunosuppressive signaling. Combining immune checkpoint targeted approaches with each other or with other receptor targets is a promising schema for future therapeutic regimen designs.

SUBMITTER: Zahavi DJ

PROVIDER: S-EPMC6337574 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Targeting Multiple Receptors to Increase Checkpoint Blockade Efficacy.

Zahavi David J DJ Weiner Louis M LM

International journal of molecular sciences 20190104 1

Immune checkpoint blockade therapy is a powerful treatment strategy for many cancer types. Many patients will have limited responses to monotherapy targeted to a single immune checkpoint. Both inhibitory and stimulatory immune checkpoints continue to be discovered. Additionally, many receptors previously identified to play a role in tumor formation and progression are being found to have immunomodulatory components. The success of immunotherapy depends on maximizing pro-anti-tumor immunity while ...[more]

PMID: 30621125

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