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Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer (iDTR scRNA-seq)

ABSTRACT: We report that airway epithelial club cells affected the immune landscaping in HKP1 lungs

ORGANISM(S): Mus musculus

PROVIDER: GSE157882 | GEO | 2021/06/08

REPOSITORIES: GEO

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Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer (0Gy4Gy scRNA-seq)

Project description:We report that airway epithelial club cells harbor the genes specifically up-regulated by 4Gy-RT

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Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer (Bulk048 RNA-seq)

Project description:We uncovered an essential role of radiationtherapy (RT)-activated lung residential Scgb1a1+ club cells in synergizing efficacy of immuno-checkpoint inhibitors. We explored the mechanisms underlying RT by analyzing the differentially-regulated genes in tumor micro-environment.

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Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

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Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer

Project description:Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer

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Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer (0Gy4Gy scRNA-seq)

Project description:Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer (0Gy4Gy scRNA-seq)

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Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer (Bulk048 RNA-seq)

Project description:Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer (Bulk048 RNA-seq)

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Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer (iDTR scRNA-seq)

Project description:Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer (iDTR scRNA-seq)

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Bronchiolar progenitors and club cells in mouse lung

Project description:Gene expression patterns of bronchiolar progenitors and club cells in mouse lung were examined by microarray experiments. Although it has not yet been fully characterized, a subset of epithelial cells lining bronchioles are best understood as bronchiolar progenitors that self-renew over the long term and that can differentiate into more differentiated club cells and ciliated cells. The bronchiolar progenitors are distinct from club cells and characteristically express the alveolar type 2 cell marker, prosurfactant protein C, with lower levels of club cell secretory protein/Scgb1a1. There are also functional differences between them; while club cells can be depleted by naphthalene because of the abundance of cytochrome P450 enzyme Cyp2f2, bronchiolar progenitors are resistant to naphthalene-induced depletion because of defects in the enzyme.

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