Lessons Learned from Checkpoint Blockade Targeting PD-1 in Multiple Myeloma.
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ABSTRACT:
SUBMITTER: Lesokhin AM
PROVIDER: S-EPMC6891823 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Lessons Learned from Checkpoint Blockade Targeting PD-1 in Multiple Myeloma.
Lesokhin Alexander M AM Bal Susan S Badros Ashraf Z AZ
Cancer immunology research 20190801 8
Immune checkpoints and agonists modulate ongoing, antigen-specific immune responses. Therapeutic blockade of CTLA-4, PD-1, and PD-L1 has proven to be an effective treatment approach for a subset of patients with a variety of cancers of epithelial, mesenchymal, or hematologic origin. In multiple myeloma, a B-cell lymphoid malignancy of terminally differentiated plasma cells, PD-1 pathway blockade is ineffective as a single agent. The initial promise in combination approaches utilizing anti-PD-1 w ...[more]
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