Ontology highlight
ABSTRACT:
SUBMITTER: Boyle KE
PROVIDER: S-EPMC6339562 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Boyle Kristopher E KE Boger Dale L DL Wroe Andrew A Vazquez Marcelo M
Bioorganic & medicinal chemistry letters 20180404 16
New treatment modalities for glioblastoma multiforme (GBM) are urgently needed. Proton therapy is considered one of the most effective forms of radiation therapy for GBM. DNA alkylating agents such as temozolomide (TMZ) are known to increase the radiosensitivity of GBM to photon radiation. TMZ is a fairly impotent agent, while duocarmycin SA (DSA) is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Here, the effects of sub-nM concentrations o ...[more]