Ontology highlight
ABSTRACT:
SUBMITTER: Bruschweiler S
PROVIDER: S-EPMC4527935 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Brüschweiler Sven S Yang Qin Q Run Changqing C Chou James J JJ
Nature structural & molecular biology 20150713 8
The ADP/ATP carrier (AAC) transports ADP and ATP across the inner mitochondrial membrane. Unlike most transporters, which have two-fold direct or inverted quasisymmetry, AAC has apparent three-fold rotational symmetry. Further, its transport rate is relatively fast for transporters that carry large solutes. Here, we study the yeast AAC carrier 3 by obtaining comprehensive NMR relaxation dispersion measurements, which provide residue-specific information on the protein's conformational exchange. ...[more]