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Stop fRETting the Target: Next-Generation RET Inhibitors Have Arrived.

ABSTRACT: BLU-667 is a next-generation RET inhibitor that maximizes on-target and minimizes off-target effects. It is an exemplar of genotype-driven drug development followed by multi-histology basket trial validation that is becoming a paradigm for precision oncology. Cancer Discov; 8(7); 797-9. ©2018 AACRSee related article by Subbiah et al., p. 836.

SUBMITTER: Iams WT 

PROVIDER: S-EPMC6345252 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Stop fRETting the Target: Next-Generation RET Inhibitors Have Arrived.

Iams Wade T WT   Lovly Christine M CM  

Cancer discovery 20180701 7

<b> BLU-667 is a next-generation RET inhibitor that maximizes on-target and minimizes off-target effects. It is an exemplar of genotype-driven drug development followed by multi-histology basket trial validation that is becoming a paradigm for precision oncology. <i>Cancer Discov; 8(7); 797-9. ©2018 AACR</i><i>See related article by Subbiah et al., p. 836</i>.</b> ...[more]

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