Ontology highlight
ABSTRACT:
SUBMITTER: Hwang JH
PROVIDER: S-EPMC6345998 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Hwang Jun-Ha JH Kim A Rum AR Kim Kyung Min KM Il Park Jung J Oh Ho Taek HT Moon Sung A SA Byun Mi Ran MR Jeong Hana H Kim Hyo Kyung HK Yaffe Michael B MB Hwang Eun Sook ES Hong Jeong-Ho JH
Nature communications 20190124 1
Insulin regulates blood glucose levels by binding its receptor and stimulating downstream proteins through the insulin receptor substrate (IRS). Impaired insulin signalling leads to metabolic syndrome, but the regulation of this process is not well understood. Here, we describe a novel insulin signalling regulatory pathway involving TAZ. TAZ upregulates IRS1 and stimulates Akt- and Glut4-mediated glucose uptake in muscle cells. Muscle-specific TAZ-knockout mice shows significantly decreased Irs1 ...[more]