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Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo.

ABSTRACT: Lung metastasis markedly reduces the prognosis of osteosarcoma. Moreover, there is no effective treatment for lung metastasis, and a new treatment strategy for the treatment of osteosarcoma lung metastasis is required. Therefore, in this study, we investigated the suppressive effect of the microtubule inhibitor eribulin mesylate (eribulin) on lung metastasis of osteosarcoma. At concentrations >proliferation IC50, eribulin induced cell cycle arrest and apoptosis in a metastatic osteosarcoma cell line, LM8. However, at concentrations

SUBMITTER: Watanabe K 

PROVIDER: S-EPMC6349434 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Low-dose eribulin reduces lung metastasis of osteosarcoma <i>in vitro</i> and <i>in vivo</i>.

Watanabe Kenta K   Yui Yoshihiro Y   Sasagawa Satoru S   Suzuki Kayo K   Kanamori Masahiko M   Yasuda Taketoshi T   Kimura Tomoatsu T  

Oncotarget 20190104 2

Lung metastasis markedly reduces the prognosis of osteosarcoma. Moreover, there is no effective treatment for lung metastasis, and a new treatment strategy for the treatment of osteosarcoma lung metastasis is required. Therefore, in this study, we investigated the suppressive effect of the microtubule inhibitor eribulin mesylate (eribulin) on lung metastasis of osteosarcoma. At concentrations >proliferation IC<sub>50</sub>, eribulin induced cell cycle arrest and apoptosis in a metastatic osteosa  ...[more]

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