Ontology highlight
ABSTRACT:
SUBMITTER: Diesch J
PROVIDER: S-EPMC6349880 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Diesch Jeannine J Bywater Megan J MJ Sanij Elaine E Cameron Donald P DP Schierding William W Brajanovski Natalie N Son Jinbae J Sornkom Jirawas J Hein Nadine N Evers Maurits M Pearson Richard B RB McArthur Grant A GA Ganley Austen R D ARD O'Sullivan Justin M JM Hannan Ross D RD Poortinga Gretchen G
Communications biology 20190128
The three-dimensional organization of the genome contributes to its maintenance and regulation. While chromosomal regions associate with nucleolar ribosomal RNA genes (rDNA), the biological significance of rDNA-genome interactions and whether they are dynamically regulated during disease remain unclear. rDNA chromatin exists in multiple inactive and active states and their transition is regulated by the RNA polymerase I transcription factor UBTF. Here, using a MYC-driven lymphoma model, we demon ...[more]