Ontology highlight
ABSTRACT:
SUBMITTER: Ponder J
PROVIDER: S-EPMC3229241 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Marine drugs 20111118 11
Type IIα DNA topoisomerase (TopoIIα) is among the most important clinical drug targets for the treatment of cancer. Recently, the DNA repair protein Metnase was shown to enhance TopoIIα activity and increase resistance to TopoIIα poisons. Using in vitro DNA decatenation assays we show that neoamphimedine potently inhibits TopoIIα-dependent DNA decatenation in the presence of Metnase. Cell proliferation assays demonstrate that neoamphimedine can inhibit Metnase-enhanced cell growth with an IC(50) ...[more]