Ontology highlight
ABSTRACT:
SUBMITTER: Kim JS
PROVIDER: S-EPMC6353903 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Kim Jeong Seon JS Kim Eun Ju EJ Lee Sieun S Tan Xiaochao X Liu Xin X Park Sanghui S Kang Keunsoo K Yoon Jung-Sook JS Ko Yoon Ho YH Kurie Jonathan M JM Ahn Young-Ho YH
Experimental & molecular medicine 20190117 1
Three miR-34 family members (miR-34a, miR-34b, and miR-34c) are clustered on two different chromosomal loci, Mir34a and Mir34b/c. These miRNAs have identical seed sequences, which are predicted to target the same set of genes. However, miR-34a and miR-34c have different sets of negatively correlated genes in lung adenocarcinoma data from The Cancer Genome Atlas. Therefore, we hypothesized that the individual miR-34 family members, which are tumor suppressive miRNAs, would have varying effects on ...[more]