Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC2752535 | biostudies-other | 2009 Sep
REPOSITORIES: biostudies-other
Li Qisheng Q Brass Abraham L AL Ng Aylwin A Hu Zongyi Z Xavier Ramnik J RJ Liang T Jake TJ Elledge Stephen J SJ
Proceedings of the National Academy of Sciences of the United States of America 20090827 38
Hepatitis C virus (HCV) infection is a major cause of end-stage liver disease and a leading indication for liver transplantation. Current therapy fails in many instances and is associated with significant side effects. HCV encodes only a few proteins and depends heavily on host factors for propagation. Each of these host dependencies is a potential therapeutic target. To find host factors required by HCV, we completed a genome-wide small interfering RNA (siRNA) screen using an infectious HCV cel ...[more]