Ontology highlight
ABSTRACT:
SUBMITTER: Beadnell TC
PROVIDER: S-EPMC6358502 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Beadnell Thomas C TC Scheid Adam D AD Vivian Carolyn J CJ Welch Danny R DR
Cancer metastasis reviews 20181201 4
Mitochondrial DNA (mtDNA) encodes for only a fraction of the proteins that are encoded within the nucleus, and therefore has typically been regarded as a lesser player in cancer biology and metastasis. Accumulating evidence, however, supports an increased role for mtDNA impacting tumor progression and metastatic susceptibility. Unfortunately, due to this delay, there is a dearth of data defining the relative contributions of specific mtDNA polymorphisms (SNP), which leads to an inability to effe ...[more]