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Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation.

ABSTRACT: Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization.

SUBMITTER: Shrestha S

PROVIDER: S-EPMC6359247 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation.

Shrestha Sanjay S Hazelbaker Mark M Yount Amber L AL Walczak Claire E CE

Biomolecules 20181220 1

Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the ...[more]

PMID: 30577528

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