Ontology highlight
ABSTRACT:
SUBMITTER: Ng CT
PROVIDER: S-EPMC6363454 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
The Journal of cell biology 20181130 2
In dividing cells, depolymerizing spindle microtubules move chromosomes by pulling at their kinetochores. While kinetochore subcomplexes have been studied extensively in vitro, little is known about their in vivo structure and interactions with microtubules or their response to spindle damage. Here we combine electron cryotomography of serial cryosections with genetic and pharmacological perturbation to study the yeast chromosome segregation machinery in vivo. Each kinetochore microtubule has on ...[more]