Targeting growth hormone function: strategies and therapeutic applications.
Ontology highlight
ABSTRACT:
SUBMITTER: Lu M
PROVIDER: S-EPMC6367471 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Targeting growth hormone function: strategies and therapeutic applications.
Lu Man M Flanagan Jack U JU Langley Ries J RJ Hay Michael P MP Perry Jo K JK
Signal transduction and targeted therapy 20190208
Human growth hormone (GH) is a classical pituitary endocrine hormone that is essential for normal postnatal growth and has pleiotropic effects across multiple physiological systems. GH is also expressed in extrapituitary tissues and has localized autocrine/paracrine effects at these sites. In adults, hypersecretion of GH causes acromegaly, and strategies that block the release of GH or that inhibit GH receptor (GHR) activation are the primary forms of medical therapy for this disease. Overproduc ...[more]
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