Ontology highlight
ABSTRACT:
SUBMITTER: Hu W
PROVIDER: S-EPMC6368460 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Hu Wenxiang W Jiang Chunjie C Guan Dongyin D Dierickx Pieterjan P Zhang Rong R Moscati Arden A Nadkarni Girish N GN Steger David J DJ Loos Ruth J F RJF Hu Cheng C Jia Weiping W Soccio Raymond E RE Lazar Mitchell A MA
Cell stem cell 20190110 2
Thiazolidinedione drugs (TZDs) target the transcriptional activity of peroxisome proliferator activated receptor γ (PPARγ) to reverse insulin resistance in type 2 diabetes, but side effects limit their clinical use. Here, using human adipose stem cell-derived adipocytes, we demonstrate that SNPs were enriched at sites of patient-specific PPARγ binding, which correlated with the individual-specific effects of the TZD rosiglitazone (rosi) on gene expression. Rosi induction of ABCA1, which regulate ...[more]