Ontology highlight
ABSTRACT:
SUBMITTER: Venkataramana Reddy PO
PROVIDER: S-EPMC6368682 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20170209 6
A series of novel β-carbolinium bromides has been synthesized from easily accessible β-carbolines and 1-aryl-2-bromoethanones. The newly synthesized compounds were evaluated for their in vitro anticancer activity. Among the synthesized derivatives, compounds 16l, 16o and 16s exhibited potent anticancer activity with IC<sub>50</sub> values of <10μM against tested cancer cell lines. The most potent analogue 16l was broadly active against all the tested cancer cell lines (IC<sub>50</sub>=3.16-7.93μ ...[more]