Ontology highlight
ABSTRACT:
SUBMITTER: Sun M
PROVIDER: S-EPMC6370136 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 20180824 4
During cell division, chromosomes must be folded into their compact mitotic form to ensure their segregation. This process is thought to be largely controlled by the action of condensin SMC protein complexes on chromatin fibers. However, how condensins organize metaphase chromosomes is not understood. We have combined micromanipulation of single human mitotic chromosomes, sub-nanonewton force measurement, siRNA interference of condensin subunit expression, and fluorescence microscopy, to analyze ...[more]