Ontology highlight
ABSTRACT:
SUBMITTER: Gaglianone RB
PROVIDER: S-EPMC6374364 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Gaglianone Rhayanna B RB Santos Anderson Teixeira AT Bloise Flavia Fonseca FF Ortiga-Carvalho Tania Maria TM Costa Manoel Luis ML Quirico-Santos Thereza T da Silva Wagner Seixas WS Mermelstein Claudia C
Scientific reports 20190213 1
Mitochondria play an important role in providing ATP for muscle contraction. Muscle physiology is compromised in Duchenne muscular dystrophy (DMD) and several studies have shown the involvement of bioenergetics. In this work we investigated the mitochondrial physiology in fibers from fast-twitch muscle (EDL) and slow-twitch muscle (soleus) in the mdx mouse model for DMD and in control C57BL/10J mice. In our study, multiple mitochondrial respiratory parameters were investigated in permeabilized m ...[more]