Ontology highlight
ABSTRACT:
SUBMITTER: Kim KS
PROVIDER: S-EPMC6377080 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kim Kyoung Sub KS Suzuki Kenichi K Cho Hana H Youn Yu Seok YS Bae You Han YH
ACS nano 20180808 9
Herein, we describe a simple and promising nanoparticle oral delivery phenomenon and propose pathways for oral nanoparticle absorption from the gastrointestinal tract (GIT), combining apical sodium-dependent bile acid transporter-mediated cellular uptake and chylomicron transport pathways. This strategy is proven to employ bile-acid-conjugated, solid fluorescent probe nanoparticles (100 nm diameter) to exclude any potential artifacts and instability issues in observing transport pathways and mea ...[more]