Ontology highlight
ABSTRACT:
SUBMITTER: Milbury KL
PROVIDER: S-EPMC6380420 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Milbury Karissa L KL Paul Biplab B Lari Azra A Fowler Claire C Montpetit Ben B Stirling Peter C PC
Nucleus (Austin, Tex.) 20191201 1
The exosome functions to regulate the cellular transcriptome through RNA biogenesis, surveillance, and decay. Mutations in Dis3, a catalytic subunit of the RNA exosome with separable endonuclease and exonuclease activities, are linked to multiple myeloma. Here we report that a cancer-associated DIS3 allele, dis3<sup>E729K</sup>, provides evidence for DIS3 functioning in mitotic fidelity in yeast. This dis3<sup>E729K</sup> allele does not induce defects in 7S→5.8S rRNA processing, although it eli ...[more]