Ontology highlight
ABSTRACT:
SUBMITTER: De Franco S
PROVIDER: S-EPMC6384913 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
De Franco Simona S Vandenameele Julie J Brans Alain A Verlaine Olivier O Bendak Katerina K Damblon Christian C Matagne André A Segal David J DJ Galleni Moreno M Mackay Joel P JP Vandevenne Marylène M
Scientific reports 20190221 1
Transcriptomes consist of several classes of RNA that have wide-ranging but often poorly described functions and the deregulation of which leads to numerous diseases. Engineering of functionalized RNA-binding proteins (RBPs) could therefore have many applications. Our previous studies suggested that the RanBP2-type Zinc Finger (ZF) domain is a suitable scaffold to investigate the design of single-stranded RBPs. In the present work, we have analyzed the natural sequence specificity of various mem ...[more]