Ontology highlight
ABSTRACT:
SUBMITTER: Yue L
PROVIDER: S-EPMC6386722 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Yue Liang L Wang Shan S Wulf Verena V Lilienthal Sivan S Remacle Françoise F Levine R D RD Willner Itamar I
Proceedings of the National Academy of Sciences of the United States of America 20190206 8
Cellular transformations are driven by environmentally triggered complex dynamic networks, which include signal-triggered feedback processes, cascaded reactions, and switchable transformations. We apply the structural and functional information encoded in the sequences of nucleic acids to construct signal-triggered constitutional dynamic networks (CDNs) that mimic the functions of natural networks. Using predesigned hairpin structures as triggers, the network generates functional strands, which ...[more]