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Transporter oligomerisation: roles in structure and function.


ABSTRACT: Oligomerisation is a key feature of integral membrane transporters with roles in structure, function and stability. In this review, we cover some very recent advances in our understanding of how oligomerisation affects these key transporter features, with emphasis on a few groups of transporters, including the nucleobase ascorbate transporters, neurotransmitter sodium symporters and major facilitator superfamily members.

SUBMITTER: Cecchetti C 

PROVIDER: S-EPMC6393857 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Transporter oligomerisation: roles in structure and function.

Cecchetti Cristina C   Pyle Euan E   Byrne Bernadette B  

Biochemical Society transactions 20181221 1


Oligomerisation is a key feature of integral membrane transporters with roles in structure, function and stability. In this review, we cover some very recent advances in our understanding of how oligomerisation affects these key transporter features, with emphasis on a few groups of transporters, including the nucleobase ascorbate transporters, neurotransmitter sodium symporters and major facilitator superfamily members. ...[more]

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