Ontology highlight
ABSTRACT:
SUBMITTER: Ziaunys M
PROVIDER: S-EPMC6394350 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Ziaunys Mantas M Smirnovas Vytautas V
PeerJ 20190225
The ability of phenylalanine to form fibrillar nanostructures was demonstrated on multiple occasions, and such an oligomerization reaction could be the cause of cytotoxicity in patients with phenylketonuria. These findings were supported by claims that L-phenylalanine (Phe) fibrils have amyloid properties and can be detected using thioflavin T fluorescence assay. However, a part of Phe aggregation studies reported the opposite data, suggesting no amyloid structures to be formed. Due to the contr ...[more]