Ontology highlight
ABSTRACT:
SUBMITTER: Anderson R
PROVIDER: S-EPMC6396144 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Anderson Rhys R Lagnado Anthony A Maggiorani Damien D Walaszczyk Anna A Dookun Emily E Chapman James J Birch Jodie J Salmonowicz Hanna H Ogrodnik Mikolaj M Jurk Diana D Proctor Carole C Correia-Melo Clara C Victorelli Stella S Fielder Edward E Berlinguer-Palmini Rolando R Owens Andrew A Greaves Laura C LC Kolsky Kathy L KL Parini Angelo A Douin-Echinard Victorine V LeBrasseur Nathan K NK Arthur Helen M HM Tual-Chalot Simon S Schafer Marissa J MJ Roos Carolyn M CM Miller Jordan D JD Robertson Neil N Mann Jelena J Adams Peter D PD Tchkonia Tamara T Kirkland James L JL Mialet-Perez Jeanne J Richardson Gavin D GD Passos João F JF
The EMBO journal 20190208 5
Ageing is the biggest risk factor for cardiovascular disease. Cellular senescence, a process driven in part by telomere shortening, has been implicated in age-related tissue dysfunction. Here, we address the question of how senescence is induced in rarely dividing/post-mitotic cardiomyocytes and investigate whether clearance of senescent cells attenuates age-related cardiac dysfunction. During ageing, human and murine cardiomyocytes acquire a senescent-like phenotype characterised by persistent ...[more]