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A Genome-Scale Co-Functional Network of Xanthomonas Genes Can Accurately Reconstruct Regulatory Circuits Controlled by Two-Component Signaling Systems.


ABSTRACT: Bacterial species in the genus Xanthomonas infect virtually all crop plants. Although many genes involved in Xanthomonas virulence have been identified through molecular and cellular studies, the elucidation of virulence-associated regulatory circuits is still far from complete. Functional gene networks have proven useful in generating hypotheses for genetic factors of biological processes in various species. Here, we present a genome-scale co-functional network of Xanthomonas oryze pv. oryzae (Xoo) genes, XooNet (www.inetbio.org/xoonet/), constructed by integrating heterogeneous types of genomics data derived from Xoo and other bacterial species. XooNet contains 106,000 functional links, which cover approximately 83% of the coding genome. XooNet is highly predictive for diverse biological processes in Xoo and can accurately reconstruct cellular pathways regulated by two-component signaling transduction systems (TCS). XooNet will be a useful in silico research platform for genetic dissection of virulence pathways in Xoo.

SUBMITTER: Kim H 

PROVIDER: S-EPMC6399010 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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A Genome-Scale Co-Functional Network of <i>Xanthomonas</i> Genes Can Accurately Reconstruct Regulatory Circuits Controlled by Two-Component Signaling Systems.

Kim Hanhae H   Joe Anna A   Lee Muyoung M   Yang Sunmo S   Ma Xiaozhi X   Ronald Pamela C PC   Lee Insuk I  

Molecules and cells 20190201 2


Bacterial species in the genus <i>Xanthomonas</i> infect virtually all crop plants. Although many genes involved in <i>Xanthomonas</i> virulence have been identified through molecular and cellular studies, the elucidation of virulence-associated regulatory circuits is still far from complete. Functional gene networks have proven useful in generating hypotheses for genetic factors of biological processes in various species. Here, we present a genome-scale co-functional network of <i>Xanthomonas o  ...[more]

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