Ontology highlight
ABSTRACT:
SUBMITTER: Gordon SM
PROVIDER: S-EPMC6401118 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Scientific reports 20190305 1
Regulation of lipid absorption by enterocytes can influence metabolic status in humans and contribute to obesity and related complications. The intracellular steps of chylomicron biogenesis and transport from the Endoplasmic Reticulum (ER) to the Golgi complex have been described, but the mechanisms for post-Golgi transport and secretion of chylomicrons have not been identified. Using a newly generated Dennd5b<sup>-/-</sup> mouse, we demonstrate an essential role for this gene in Golgi to plasma ...[more]