Ontology highlight
ABSTRACT:
SUBMITTER: Das M
PROVIDER: S-EPMC6401191 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Das Manisit M Shen Limei L Liu Qi Q Goodwin Tyler J TJ Huang Leaf L
Molecular therapy : the journal of the American Society of Gene Therapy 20181117 3
Local immunomodulation can be a promising strategy to augment the efficacy and decrease off-target toxicities associated with cancer treatment. Pancreatic cancer is resistant to immunotherapies due to the immunosuppressive tumor microenvironment. Herein, we investigated a therapeutic approach involving delivery of a short interfering double-stranded RNA (dsRNA), specific to Bcl2, with 5' triphosphate ends, by lipid calcium phosphate nanoparticles, in an orthotopic allograft KPC model of pancreat ...[more]