Ontology highlight
ABSTRACT:
SUBMITTER: Wendler J
PROVIDER: S-EPMC6403363 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Wendler Judith J Schroeder Bjoern O BO Ehmann Dirk D Koeninger Louis L Mailänder-Sánchez Daniela D Lemberg Christina C Wanner Stephanie S Schaller Martin M Stange Eduard F EF Malek Nisar P NP Weidenmaier Christopher C LeibundGut-Landmann Salomé S Wehkamp Jan J
Scientific reports 20190306 1
Microbial resistance against clinical used antibiotics is on the rise. Accordingly, there is a high demand for new innovative antimicrobial strategies. The host-defense peptide human beta-defensin 1 (hBD-1) is produced continuously by epithelial cells and exhibits compelling antimicrobial activity after reduction of its disulphide bridges. Here we report that proteolysis of reduced hBD-1 by gastrointestinal proteases as well as human duodenal secretions produces an eight-amino acid carboxy-termi ...[more]