Ontology highlight
ABSTRACT:
SUBMITTER: Jezek M
PROVIDER: S-EPMC6407025 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Jezek Meagan M Green Erin M EM
Cells 20190225 2
Telomeres, the nucleoprotein structures at the ends of eukaryotic chromosomes, play an integral role in protecting linear DNA from degradation. Dysregulation of telomeres can result in genomic instability and has been implicated in increased rates of cellular senescence and many diseases, including cancer. The integrity of telomeres is maintained by a coordinated network of proteins and RNAs, such as the telomerase holoenzyme and protective proteins that prevent the recognition of the telomere e ...[more]