Ontology highlight
ABSTRACT:
SUBMITTER: Bobadilla AVP
PROVIDER: S-EPMC6408363 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Bobadilla Ana Victoria Ponce AVP Arévalo Jazmine J Sarró Eduard E Byrne Helen M HM Maini Philip K PK Carraro Thomas T Balocco Simone S Meseguer Anna A Alarcón Tomás T
Journal of the Royal Society, Interface 20190201 151
The scratch assay is an in vitro technique used to assess the contribution of molecular and cellular mechanisms to cell migration. The assay can also be used to evaluate therapeutic compounds before clinical use. Current quantification methods of scratch assays deal poorly with irregular cell-free areas and crooked leading edges which are features typically present in the experimental data. We introduce a new migration quantification method, called 'monolayer edge velocimetry', that permits anal ...[more]