Ontology highlight
ABSTRACT:
SUBMITTER: Lim CZJ
PROVIDER: S-EPMC6408581 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Lim Carine Z J CZJ Zhang Yan Y Chen Yu Y Zhao Haitao H Stephenson Mary C MC Ho Nicholas R Y NRY Chen Yuan Y Chung Jaehoon J Reilhac Anthonin A Loh Tze Ping TP Chen Christopher L H CLH Shao Huilin H
Nature communications 20190308 1
Despite intense interests in developing blood measurements of Alzheimer's disease (AD), the progress has been confounded by limited sensitivity and poor correlation to brain pathology. Here, we present a dedicated analytical platform for measuring different populations of circulating amyloid β (Aβ) proteins - exosome-bound vs. unbound - directly from blood. The technology, termed amplified plasmonic exosome (APEX), leverages in situ enzymatic conversion of localized optical deposits and double-l ...[more]