Dataset Information

MiR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years.

ABSTRACT:

Introduction

Alterations in miR-155 serum levels have been described in inflammatory and infectious diseases. Moreover, a role for miR-155 in aging and age-related diseases was recently suggested. We therefore analyzed a potential age-dependent prognostic value of circulating miR-155 as a serum-based marker in critical illness.

Methods

Concentrations of circulating miR-155 were determined in 218 critically ill patients and 76 healthy controls.

Results

By using qPCR, we demonstrate that miR-155 serum levels are elevated in patients with critical illness when compared to controls. Notably, levels of circulating miR-155 were independent on the severity of disease, the disease etiology, or the presence of sepsis. In the total cohort, miR-155 was not an indicator for patient survival. Intriguingly, when patients were subdivided according to their age upon admission to the ICU into those younger than 65 years, lower levels of miR-155 turned out as a strong marker, indicating patient mortality with a similar accuracy than other markers frequently used to evaluate critically ill patients on a medical ICU.

Conclusion

In summary, the data provided within this study suggest an age-specific role of miR-155 as a prognostic biomarker in patients younger than 65 years. Our study is the first to describe an age-dependent miRNA-based prognostic biomarker in human diseases.

SUBMITTER: Tacke F

PROVIDER: S-EPMC6409014 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years.

Tacke Frank F Spehlmann Martina E ME Vucur Mihael M Benz Fabian F Luedde Mark M Cardenas David Vargas DV Roy Sanchari S Loosen Sven S Hippe Hans-Joerg HJ Frey Norbert N Trautwein Christian C Koch Alexander A Roderburg Christoph C Luedde Tom T

Mediators of inflammation 20190224

<h4>Introduction</h4>Alterations in miR-155 serum levels have been described in inflammatory and infectious diseases. Moreover, a role for miR-155 in aging and age-related diseases was recently suggested. We therefore analyzed a potential age-dependent prognostic value of circulating miR-155 as a serum-based marker in critical illness.<h4>Methods</h4>Concentrations of circulating miR-155 were determined in 218 critically ill patients and 76 healthy controls.<h4>Results</h4>By using qPCR, we demo ...[more]

PMID: 30918471

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