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Briarenones A?C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum.

ABSTRACT: Three new eunicellin-derived diterpenoids of briarellin type, briarenones A?C (1?3), were isolated from a Formosan gorgonian Briareum violaceum. The chemical structures of the compounds were elucidated on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR. The absolute configuration of 1 was further confirmed by a single crystal X-ray diffraction analysis. The in vitro cytotoxic and anti-inflammatory potentialities of the isolated metabolites were tested against the growth of a limited panel of cancer cell lines and against the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenyl-alanine and cytochalasin B (fMLF/CB)-stimulated human neutrophils, respectively.

SUBMITTER: Cheng Y

PROVIDER: S-EPMC6409734 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Briarenones A‒C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum.

Cheng Yang Y Ahmed Atallah F AF Orfali Raha S RS Dai Chang-Feng CF Sheu Jyh-Horng JH

Marine drugs 20190217 2

Three new eunicellin-derived diterpenoids of briarellin type, briarenones A‒C (1‒3), were isolated from a Formosan gorgonian Briareum violaceum. The chemical structures of the compounds were elucidated on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR. The absolute configuration of 1 was further confirmed by a single crystal X-ray diffraction analysis. The in vitro cytotoxic and anti-inflammatory potentialities of the isolated metabo ...[more]

PMID: 30781569

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