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Exploration of Indole Alkaloids from Marine Fungus Pseudallescheria boydii F44-1 Using an Amino Acid-Directed Strategy.


ABSTRACT: The composition of the culture medium has great influence on the metabolite production of the marine fungus Pseudallescheria boydii F44-1. By adding amino acids to GPY culture medium, two new bisindole alkaloids, pseudboindoles A and B (1 and 2), together with 11 known indole alkaloids were isolated from the culture broth. Their structures were elucidated by comprehensive analysis of the NMR, MS, IR, and UV spectra. The 3,3'-cyclohexylidenebis(1H-indole) (3) showed cytotoxic activity against various cancer cell lines.

SUBMITTER: Yuan MX 

PROVIDER: S-EPMC6410255 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Exploration of Indole Alkaloids from Marine Fungus <i>Pseudallescheria boydii</i> F44-1 Using an Amino Acid-Directed Strategy.

Yuan Mei-Xiang MX   Qiu Yi Y   Ran Yan-Qin YQ   Feng Gong-Kan GK   Deng Rong R   Zhu Xiao-Feng XF   Lan Wen-Jian WJ   Li Hou-Jin HJ  

Marine drugs 20190123 2


The composition of the culture medium has great influence on the metabolite production of the marine fungus <i>Pseudallescheria boydii</i> F44-1. By adding amino acids to GPY culture medium, two new bisindole alkaloids, pseudboindoles A and B (<b>1</b> and <b>2</b>), together with 11 known indole alkaloids were isolated from the culture broth. Their structures were elucidated by comprehensive analysis of the NMR, MS, IR, and UV spectra. The 3,3'-cyclohexylidenebis(1<i>H</i>-indole) (<b>3</b>) sh  ...[more]

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