Ontology highlight
ABSTRACT:
SUBMITTER: Eliseeva I
PROVIDER: S-EPMC6410274 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Genes 20190129 2
The mammalian target of rapamycin (mTOR) kinase is a well-known master regulator of growth-dependent gene expression in higher eukaryotes. Translation regulation is an important function of the mTORC1 pathway that controls the synthesis of many ribosomal proteins and translation factors. Housekeeping genes such as <i>β-actin</i> (<i>ACTB</i>) are widely used as negative control genes in studies of growth-dependent translation. Here we demonstrate that translation of both endogenous and reporter ...[more]