Ontology highlight
ABSTRACT:
SUBMITTER: de Almeida BP
PROVIDER: S-EPMC6411098 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
de Almeida Bernardo P BP Vieira André F AF Paredes Joana J Bettencourt-Dias Mónica M Barbosa-Morais Nuno L NL
PLoS computational biology 20190311 3
Centrosome amplification (CA) is a common feature of human tumours and a promising target for cancer therapy. However, CA's pan-cancer prevalence, molecular role in tumourigenesis and therapeutic value in the clinical setting are still largely unexplored. Here, we used a transcriptomic signature (CA20) to characterise the landscape of CA-associated gene expression in 9,721 tumours from The Cancer Genome Atlas (TCGA). CA20 is upregulated in cancer and associated with distinct clinical and molecul ...[more]