Ontology highlight
ABSTRACT:
SUBMITTER: Lee MJ
PROVIDER: S-EPMC6411724 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Lee Min Jae MJ Miller Zachary Z Park Ji Eun JE Bhattarai Deepak D Lee Wooin W Kim Kyung Bo KB
Scientific reports 20190311 1
The second-in-class proteasome inhibitor (PI) carfilzomib (Kyprolis, Cfz) has contributed to a substantial advancement in multiple myeloma treatment by improving patient survival and quality of life. A considerable portion of patients however display intrinsic resistance to Cfz. Our mechanistic understanding of intrinsic Cfz resistance is limited due to a lack of suitable cell-based models. We report that H727 human bronchial carcinoid cells are inherently resistant to Cfz, yet susceptible to ot ...[more]