Ontology highlight
ABSTRACT:
SUBMITTER: Lumsden AL
PROVIDER: S-EPMC6412251 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Lumsden Amanda L AL Martin Alyce M AM Sun Emily W EW Schober Gudrun G Isaacs Nicole J NJ Pezos Nektaria N Wattchow David A DA de Fontgalland Dayan D Rabbitt Philippa P Hollington Paul P Sposato Luigi L Due Steven L SL Rayner Christopher K CK Nguyen Nam Q NQ Liou Alice P AP Jackson V Margaret VM Young Richard L RL Keating Damien J DJ
Nutrients 20190122 2
Gut-derived serotonin (5-HT) is released from enterochromaffin (EC) cells in response to nutrient cues, and acts to slow gastric emptying and modulate gastric motility. Rodent studies also evidence a role for gut-derived 5-HT in the control of hepatic glucose production, lipolysis and thermogenesis, and in mediating diet-induced obesity. EC cell number and 5-HT content is increased in the small intestine of obese rodents and human, however, it is unknown whether EC cells respond directly to gluc ...[more]