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Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018.

ABSTRACT: We describe detection in the United Kingdom (UK) of the drug-resistant Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate azithromycin resistance. Two female patients developed infection following contact with UK-resident men from the same sexual network linked to travel to Ibiza, Spain. One case failed treatment with ceftriaxone, and azithromycin and gentamicin, before successful treatment with ertapenem. Both isolates had indistinguishable whole-genome sequences. Urgent action is essential to contain this drug-resistant strain.

SUBMITTER: Eyre DW 

PROVIDER: S-EPMC6415501 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Detection in the United Kingdom of the <i>Neisseria gonorrhoeae</i> FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018.

Eyre David W DW   Town Katy K   Street Teresa T   Barker Leanne L   Sanderson Nicholas N   Cole Michelle J MJ   Mohammed Hamish H   Pitt Rachel R   Gobin Maya M   Irish Charles C   Gardiner Daniel D   Sedgwick James J   Beck Charles C   Saunders John J   Saunders John J   Turbitt Deborah D   Cook Clare C   Phin Nick N   Nathan Bavithra B   Horner Paddy P   Fifer Helen H  

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20190301 10

We describe detection in the United Kingdom (UK) of the drug-resistant <i>Neisseria gonorrhoeae</i> FC428 clone, with ceftriaxone resistance and intermediate azithromycin resistance. Two female patients developed infection following contact with UK-resident men from the same sexual network linked to travel to Ibiza, Spain. One case failed treatment with ceftriaxone, and azithromycin and gentamicin, before successful treatment with ertapenem. Both isolates had indistinguishable whole-genome seque  ...[more]

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